HADDOCK

High Ambiguity Driven biomolecular DOCKing

based on biochemical and/or biophysical information.

Structure + Binformatic/Biophysical Data => Complex

Version: 2.2 (March, 2015) (changes)

Authors: Alexandre Bonvin and members of the computational structural biology group, Utrecht University

Contact:

HADDOCK is one of the flagship software in the EU H2020 BioExcel Center of Excellence for Biomolecular Research

HADDOCK online (setup your run): https://www.bonvinlab.org/software/haddock2.2/haddock-start

HADDOCK manual: https://www.bonvinlab.org/software/haddock2.2/manual

HADDOCK webserver: https://alcazar.science.uu.nl/services/HADDOCK2.2

HADDOCK grid-enabled webserver: https://alcazar.science.uu.nl/enmr/services/HADDOCK2.2

Getting the software: license form

Questions about HADDOCK or looking for support? Ask BioExcel

A short introduction: View the BioExcel CoE webinar about HADDOCK

Publications:

When using HADDOCK cite:

Cyril Dominguez, Rolf Boelens and Alexandre M.J.J. Bonvin. HADDOCK: a protein-protein docking approach based on biochemical and/or biophysical information.
J. Am. Chem. Soc. 125, 1731-1737 (2003).

G.C.P van Zundert, J.P.G.L.M. Rodrigues, M. Trellet, C. Schmitz, P.L. Kastritis, E. Karaca, A.S.J. Melquiond, M. van Dijk, S.J. de Vries and A.M.J.J. Bonvin. "The HADDOCK2.2 webserver: User-friendly integrative modeling of biomolecular complexes."
J. Mol. Biol., 428, 720-725 (2016).

For additional citations when using specific modules see also our publication page.

Acknowledgments:

HADDOCK is derived from ARIA scripts by Michael Nilges and Jens Linge.

J.P. Linge, M. Habeck, W. Rieping and M. Nilges (2003). ARIA: automated NOE assignment and NMR structure calculation. Bioinformatics 19, 315-316.

The ongoing development of HADDOCK is the result of a team effort and in particular contributions from Cyril Dominguez, Aalt-Jan van Dijk, Sjoerd de Vries, Marc van Dijk, Ezgi Karaca, Panagiotis Kastritis, Adrien Melquiond, Mikael Trellet, Gydo van Zundert and Joao Rodrigues are acknowledged.